Delay in health-care-seeking treatment among tuberculosis patients in Japan: what are the implications for control in the era of universal health coverage?

Authors

  • Reina Yoshikawa Department of General Internal Medicine, Rakuwakai Marutamachi Hospital, Kyoto, Japan
  • Lisa Kawatsu Department of Epidemiology and Clinical Research, the Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan
  • Kazuhiro Uchimura Department of Epidemiology and Clinical Research, the Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan
  • Akihiro Ohkado Department of Epidemiology and Clinical Research, the Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan; Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

DOI:

https://doi.org/10.5365/wpsar.2019.10.1.010

Abstract

Objective: To study the trends in and risk factors for patient delay (the time from the onset of symptoms to the initial doctor visit) in pulmonary tuberculosis (PTB) using three temporal categories - short (2 weeks to < 2 months), medium (2 months to < 6 months) and long (>= 6 months) - and discuss implications for social protection measures.

Methods: A descriptive cross-sectional study was conducted by analysing Japanese TB surveillance data from patients with symptomatic PTB registered between 2007 and 2017 (n = 88 351).

Results: While the proportion of patients with short delay has decreased significantly (P < 0.001), the proportions of those with medium or long delays have decreased slightly (P = 0.0015 and P < 0.001, respectively). Not having health insurance, receiving public assistance, being a temporary worker, and having a history of homelessness were some of the risks identified for patient delay. Being male and working full-time were two risks specifically associated with long delay (for males, the adjusted odds ratio = 1.17, P < 0.05; for being a full-time worker, the adjusted odds ratio = 1.72, P < 0.05).

Discussion: Despite the implementation of universal health coverage decades ago, patient delay remains a challenge in Japan. Our study identified various risk factors, many of which could have been resolved if appropriate social protection measures were in place, indicating shortcomings in universal health coverage in Japan and the need for continued effort to ensure that no one is left behind.

Author Biographies

Reina Yoshikawa, Department of General Internal Medicine, Rakuwakai Marutamachi Hospital, Kyoto, Japan

department of general internal medicine

Lisa Kawatsu, Department of Epidemiology and Clinical Research, the Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan

department of epidemiology and clinical research

Kazuhiro Uchimura, Department of Epidemiology and Clinical Research, the Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan

department of epidemiology ang clinical research

Akihiro Ohkado, Department of Epidemiology and Clinical Research, the Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan; Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

department of epidemiology and clinical research

References

(1) Global Tuberculosis Report 2018. Geneva: World Health Organization; 2018 (https://apps.who.int/iris/bitstream/handle/10665/274453/9789241565646-eng.pdf?ua=1, accessed 15 February 2019).

(2) Global strategy and targets for tuberculosis prevention, care and control after 2015. Geneva: Sixty-Seventh World Health Assembly; 2014 (http://apps.who.int/gb/ebwha/pdf_files/WHA67/A67_R1-en.pdf, accessed 15 February 2019).

(3) Ward HA, Marciniuk DD, Pahwa P, Hoeppner VH. Extent of pulmonary tuberculosis in patients diagnosed by active compared to passive case finding. Int J Tuberc Lung Dis. 2004;8(5):593-597.

(4) Storla DG, Yimer S, Bjune GA. A systematic review of delay in the diagnosis and treatment of tuberculosis. BMJ Public Health. 2008;8(15).

(5) Cai J, Wang X, Ma A, Wang Q, Han X, Li Y. Factors associated with patient and provider delays for tuberculosis diagnosis and treatment in Asia: a systematic review and meta-analysis. PLoS One. 2015;10(3):e0120088.

(6) Implementing The End TB Strategy: The Essentials. Geneva: World Health Organization; 2015 (https://www.who.int/tb/publications/2015/end_tb_essential.pdf, accessed 15 February 2019).

(7) UHC and SDG Country Profile 2018 Japan. Manila: World Health Organization Western Pacific Region; 2018 (http://iris.wpro.who.int/bitstream/handle/10665.1/14046/WPR-2018-DHS-007-jpn-eng.pdf, accessed 15 February 2019).

(8) Tuberculosis in Japan: Annual Report 2018. Japan: Tuberculosis Surveillance Center-RIT/JATA; 2018 (http://www.jata.or.jp/rit/ekigaku/en/statistics-of-tb/, accessed 15 February 2019).

(9) Hopewell PC, Pai M, Maher D, Uplekar M, Raviglione MC. International standards for tuberculosis care. Lancet Infect Dis. 2006;6(11):710-25.

(10) Getnet F, Demissie M, Assefa N, Mengistie B, Worku A. Delay in diagnosis of pulmonary tuberculosis in low-and middle-income settings: systematic review and meta-analysis. BMJ Pulm Med. 2017;17:202.

(11) Li Y, Ehiri J, Tang S, Li D, Bian Y, Lin H, et al. Factors associated with patient, and diagnostic delay in Chinese TB patients: a systematic review and meta-analysis. BMC Med. 2013;11:156.

(12) Tattevin P, Che D, Fraisse P, Gatey C, Guichard C, Antoine D, et al. Factors associated with patient and health care system delay in the diagnosis of tuberculosis in France. Int J Tuberc Lung Dis. 2012;16(4):510-515.

(13) Rojpibulstit, M,Kanjanakiritamrong, J. Chongsuvivatwong V. Patient and health system delays in the diagnosis of tuberculosis in Southern Thailand after health care reform. Int J Tuberc Lung Dis. 2016;10(4):422-428.

(14) Ikegami N, Yoo BK, Hashimoto H, Matsumoto M, Ogata H, Babazono A, et al. Japanese universal health coverage: evolution, achievements, and challenges. Lancet. 2011;378(9796):1106-15.

(15) Japan Youth Statement Universal Health Coverage, A Chance for All. Japan: UHC Youth Japan; 2017 (http://uhcday.jp/wordpress/wp-content/uploads/2017/12/Japan-Youth-Statement-UHC_R1-English.pdf, accessed 15 February 2019).

(16) Kokuho shikaku shomeisho wo koufu sareta hihokensha no jushinritu no chosakekka ni tsuite (“Reports on frequency of outpatient clinic utilization among people not having health insurance”). Japan: Japan Medical Practitioner’s Association; 2010 (https://hodanren.doc-net.or.jp/news/tyousa/101129kokuho/kekka.pdf, accessed 15 February 2019). (in Japanese)

(17) Iryo fujo no tekiseika, seikatsuhogo jukyu sha no kenkou kanri nitsuite (“Current situation of general health care among people receiving social welfare”). Japan: Ministry of Health, Labour, and Welfare; 2017 (https://www.mhlw.go.jp/file/05-Shingikai-12601000-Seisakutoukatsukan-Sanjikanshitsu_Shakaihoshoutantou/0000169132_5.pdf, accessed 15 February 2019). (in Japanese)

(18) Matsunami Y, Kawai A. Smoking among recipients of public assistance benefits from N city, and their recognition of smoking cessation therapy. Journal of Japan Society for Tobacco Control. 2015;10:51-58. (in Japanese)

(19) Deta ni motoduita seikatsuhogo jukyu sha no kenkou kanri sien nitsuite (“Current situation of general health care among people receiving social welfare”). Japan: Ministry of Health, Labour, and Welfare; 2017 (https://www.mhlw.go.jp/file/05-Shingikai-12201000-Shakaiengokyokushougaihokenfukushibu-Kikakuka/sankoushiryou1.pdf, accessed 15 February 2019). (in Japanese)

(20) Tomita S, Santoku K. Sounenki ni aru seikatsuhogo jukyusha no kenkoukoudou to kadai (“Health Behaviors of Middle Aged Public Assistance Recipients: Problems and Challenges”). Kawasaki Medical Welfare Journal. 2011;21(1),145-150. (in Japanese)

(21) Leung EC, Leung CC, Tam CM. Delayed presentation and treatment of newly diagnosed pulmonary tuberculosis patients in Hong Kong. Hong Kong Med J. 2007;13(3):221-7.

(22) Basnet R, Hinderaker SG, Enarson D, Malla P, Mørkve O. Delay in the diagnosis of tuberculosis in Nepal. BMC Public Health. 2009;14(9):236.

(23) Saito J, Kondo K, TakakiT. Seikatsuhogo jukyu sha ni okeru kenkou jushin kanren youin: kihon zokusei chousa wo taisho toshite (“Analysis of factors affecting participation to health checks among people receiving social welfare”). Journal of health and welfare statistics. 2018;65(5),15-20. (in Japanese)

(24) Ohmori M, Ozasa K, Mori T, Wada M, Yoshiyama T, Aoki M, et al. Trends of delays in tuberculosis case finding in Japan and associated factors. Int J Tuberc Lung Dis. 2005;9(9):999-1005.

(25) Matsumoto K, Fukunaga Y, Monbayashi J, Arima K, Shimouchi A. Investigation on “Patient’s Delay” in TB detection. Kekkaku. 2009;84(7):523-529.

(26) Oki N, Higashiyama K, Tanaka H. “Hai kekkaku kanja no jushin to shindan no okureni kannren suru youin” (Factors associated with patient and doctor delay among pulmonary tuberculosis patients). Annual Report of Hyogo Prefectural Institute of Public Health Science. 2001;35:82-88.

(27) Takatorige T, Ohsaka T, Yamamoto S, Nishimori T, Fujikawa T, Kuroda K, et al. Tuberculosis and its control measures for homeless people: implementation of chest X-ray examination for three successive years. Kekkaku. 2007;82(1):19-25.

(28) Kaguraoka S, Ohmori M, Takao Y, Yamada M, Muroi M, Nagamine M, et al. Tuberculosis control in Shinjuku Ward, Tokyo--promoting the DOTS program and its outcome. Kekkaku. 2008;83(9):611-620.

(29) Hwang J, Kihara M, Kihara. “Homuresu no hitobito no kekkakukenshin jushin koudou ni eikyouwo oyobosu youin” (A qualitative study on the factors affecting TB care seeking behavior among homeless people). Japanese Journal of Public Health. 2017;64:547. (in Japanese)

(30) Koyanagi J, Sato N, Matsuura M, et al. “Homuresu kekkaku kenshin niokeru jushinsha no joukyou” (A situational analysis of people attending homeless TB screening). Japanese Journal of Public Health. 2011; 57:398. (in Japanese)

(31) Iijima Y, Sano M (eds) “Wakamono homuresu hakusho” (A report on young homeless people). NPO Big Issue Foundation. 2010. (https://bigissue.or.jp/wp-content/uploads/2018/09/younghomeless.pdf, accessed 16 February 2019).

(32) Wakui S, Nagashima M, Hagi Y, Higasionna A, Yoshitake Y. The relationship between the specific medical check-up and the physical activity-related factors among national health insurance subscribers. Journal of Japanese Society of Lifelong Sports. 2014;10:11-20. (in Japanese)

(33) Cai J, Wang X, Ma A, WangQ, Han X, Li Y. Factors Associated with Patient and Provider Delays for Tuberculosis Diagnosis and Treatment in Asia: A Systematic Review and Meta-Analysis. PLoS ONE. 10(3):e0120088.

(34) Horton KC, Sumner T, Houben RMGJ, Corbett EL, White RG. A Bayesian Approach to Understanding Sex Differences in Tuberculosis Disease Burden. Am J Epidemiol. 2018;187(11):2431-2438.

(35) Oohashi Y, Watai I, Murashima S. Sounenki kokuho hi hokensha niokeru tokutei kenshin mijushin sha no jushi ishi (A study on attitudes and motivation towards attending a medical check-up among middle-aged persons in Japan). Japan Academy of Community Nursing. 2012;15:64-72. (in Japanese)

(36) Katoh K, Kanno S. Factors associated with cancer screenings participation rates: results from Tadami Town Health Survey 2003. Bulletin of Fukushima School of Nursing. 2009;11:29-37. (in Japanese)

(37) Bojovic O, Medenica M, Zivkovic D, Rakocevic B, Trajkovic G, Kisc-Tepavcevic, et al. Factors associated with patient and health system delays in diagnosis and treatment of tuberculosis in Montenegro, 2015–2016. PLoS ONE. 2018;3(3):e0193997.

(38) Yirgu R, Lemessa F, Hirpa S, Alemayehu A, Klinkenberg E. Determinants of delayed care seeking for TB suggestive symptoms in Seru district, Oromiya region, Ethiopia: a community based unmatched case-control study. BMC Infectious Diseases. 2017;17:292: https://doi.org/10.1186/s12879-017-2407-8

(39) Leung EC, Leung CC, Tam CM. Delay presentation and treatment of newly diagnosed pulmonary tuberculosis patients in Hong Kong. Hong Kong Med J. 2007;13:221–227.

(40) Wang W, Jiang Q, Abdullah A S,Xu B. Barriers in accessing to tuberculosis care among non-residents in Shanghai: a descriptive study of delays in diagnosis. Eur J Public Health. 2007;17:419–423.

(41) Lin Y, Enarson DA, Chiang CY, Rusen ID, Qiu LX, Kan XH, et al. Patient delay in the diagnosis and treatment of tuberculosis in China: findings of case detection projects. Public Health Action. 2015;5: http://dx.doi.org/10.5588/pha.14.0066

(42) Fujiawara A, Hara S. “Tonyobyo ga tuyoku utagawareru koureisha ga jushin wo shinai riyuni kansuru shituteki kenkyu” (A qualitative study on the reasons why patients suspected with diabetes do not seek medical care). Bulletin of Shimane University Faculty of Medicine. 2016; 38:45-53 (in Japanese)

(43) Kawatsu L, Uchimura K, Ohkado A, Izumi K. Overview of Diabetes Mellitus Among Japanese Patients With Pulmonary Tuberculosis: An Analysis of the Tuberculosis Surveillance Data. Japan Diab Soc. 2016;59(11):759-767.

(44) Farah MG, Rygh JH, Steen TW, Selmer R, Heldal E, Bjune G. Patient and health care system delays in the start of tuberculosis treatment in Norway. BMC Infect Dis. 2006;6:33.

(45) Gagliotti C, Resi D, Moro ML. Delay in the treatment of pulmonary TB in a changing demographic scenario. Int J Tuberc Lung Dis. 2006;10(3):305-309.

Published

30-06-2020

How to Cite

1.
Yoshikawa R, Kawatsu L, Uchimura K, Ohkado A. Delay in health-care-seeking treatment among tuberculosis patients in Japan: what are the implications for control in the era of universal health coverage?. Western Pac Surveill Response J [Internet]. 2020 Jun. 30 [cited 2024 Nov. 2];11(2). Available from: https://ojs.wpro.who.int/ojs/index.php/wpsar/article/view/681

Issue

Section

Original Research

Most read articles by the same author(s)