Viral load suppression and acquired HIV drug resistance in adults receiving antiretroviral therapy in Viet Nam: results from a nationally representative survey

Authors

  • Vu Quoc Dat Department of Infectious Diseases, Hanoi Medical University, Hanoi, Viet Nam https://orcid.org/0000-0002-5904-5970
  • Bui Duc Duong Viet Nam Authority of HIV/AIDS Control, Hanoi, Viet Nam
  • Do Thi Nhan Viet Nam Authority of HIV/AIDS Control, Hanoi, Viet Nam
  • Nguyen Huu Hai Viet Nam Authority of HIV/AIDS Control, Hanoi, Viet Nam
  • Nguyen Thi Lan Anh National Institute of Hygiene Epidemiology, Hanoi, Viet Nam
  • Huynh Hoang Khanh Thu Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Viet Nam
  • Tran Ton Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Viet Nam
  • Luong Que Anh Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Viet Nam
  • Nguyen Tuan Nghia National Institute of Hygiene Epidemiology, Hanoi, Viet Nam
  • Nguyen Vu Thuong Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Viet Nam
  • Khuu Van Nghia Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Viet Nam
  • Tran Thi Minh Tam National Institute of Hygiene Epidemiology, Hanoi, Viet Nam
  • Tran Phuc Hau Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Viet Nam
  • Nguyen Duy Phuc Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Viet Nam
  • Vu Xuan Thinh Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Viet Nam
  • Truong Thi Xuan Lien Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Viet Nam
  • Nguyen Tran Hien National Institute of Hygiene Epidemiology, Hanoi, Viet Nam
  • Silvia Bertagnolio World Health Organization, Geneva, Switzerland
  • Nguyen Thi Thuy Van World Health Organization Viet Nam Country Office, Hanoi, Viet Nam
  • Masaya Kato World Health Organization Viet Nam Country Office, Hanoi, Viet Nam

DOI:

https://doi.org/10.5365/wpsar.2018.9.1.008

Abstract

Objective: The purpose of this survey was to estimate the prevalence of viral load (VL) suppression and emergence of HIV drug resistance (HIVDR) among individuals receiving antiretroviral therapy (ART) for 36 months or longer in Viet Nam using a nationally representative sampling method.

Methods: The survey was conducted between May and August 2014 using a two-stage cluster design. Sixteen ART clinics were selected using probability proportional to proxy size sampling, and patients receiving ART for at least 36 months were consecutively enrolled. Epidemiological information and blood specimens were collected for HIV-1 VL and HIVDR testing; HIVDR was defined by the Stanford University HIVDR algorithm.

Results: Overall, 365 eligible individuals were recruited with a mean age of 38.2 years; 68.4% were men. The mean time on ART was 75.5 months (95% confidence interval [CI]: 69.0–81.9 months), and 93.7% of the patients were receiving non-nucleoside reverse transcriptase inhibitor-based regimens. Of the 365 individuals, 345 (95.1%, 95% CI: 92.3–96.9%) had VL below 1000 copies/mL and 19 (4.6%, 95% CI: 2.8-–7.5) had HIVDR mutations.

Discussion: Our nationally representative survey found a high level of VL suppression and a low prevalence of HIVDR among individuals who received ART for at least 36 months in Viet Nam. Continued surveillance for HIVDR is important for evaluating and improving HIV programs.

Author Biography

Tran Thi Minh Tam, National Institute of Hygiene Epidemiology, Hanoi, Viet Nam

National Institute of Hygiene Epidemiology

References

The Joint United Nations Programme on HIV/AIDS (UNAIDS) Vietnam. Know your epidemic 2017 [Available from: http://unaids.org.vn/en/know-your-epidemic/.

VAAC. Global AIDS Monitoring 2017 - Report from Vietnam. Hanoi, Vietnam: Viet Nam Authority of HIV/AIDS Control; 2017.

Vietnam Ministry of Health. Reporting on HIV/AIDS prevention in 2015 and important mission in 2016. 2016.

Jordan MR, Bennett DE, Bertagnolio S, Gilks CF, Sutherland D. World Health Organization surveys to monitor HIV drug resistance prevention and associated factors in sentinel antiretroviral treatment sites. Antivir Ther. 2008;13 Suppl 2:15-23.

WHO. Surveillance of HIV drug resistance in adults receiving ART (acquired HIV drug resistance). Geneva, Switzerland: World Health Organization; 2014.

World Health Organization. Surveillance of HIV drug resistance in adults receiving ART (acquired HIV drug resistance). Geneva, Switzerland: WHO Document Production Services; 2014.

HIVdb Program: Genotypic Resistance Interpretation Algorithm [Internet]. [cited 15th May 2015]. Available from: http://hivdb.stanford.edu/index.html.

World Health Organization USCfDCaP, The Global Fund to Fight AIDS, Tuberculosis and Malaria. HIV drug resistance report 2017. Geneva, Switzerland: World Health Organization; 2017. Available from: http://www.who.int/hiv/pub/drugresistance/hivdr-report-2017/en/.

Nguyen HT, Duc NB, Shrivastava R, Tran TH, Nguyen TA, Thang PH, et al. HIV drug resistance threshold survey using specimens from voluntary counselling and testing sites in Hanoi, Vietnam. Antivir Ther. 2008;13 Suppl 2:115-21.

Duc NB, Hien BT, Wagar N, Tram TH, Giang le T, Yang C, et al. Surveillance of transmitted HIV drug resistance using matched plasma and dried blood spot specimens from voluntary counseling and testing sites in Ho Chi Minh City, Vietnam, 2007-2008. Clin Infect Dis. 2012;54 Suppl 4:S343-7.

Tanuma J, Quang VM, Hachiya A, Joya A, Watanabe K, Gatanaga H, et al. Low prevalence of transmitted drug resistance of HIV-1 during 2008-2012 antiretroviral therapy scaling up in Southern Vietnam. J Acquir Immune Defic Syndr. 2014;66(4):358-64.

Pham QD, Do NT, Le YN, Nguyen TV, Nguyen DB, Huynh TK, et al. Pretreatment HIV-1 drug resistance to first-line drugs: results from a baseline assessment of a large cohort initiating ART in Vietnam, 2009-10. The Journal of antimicrobial chemotherapy. 2015;70(3):941-7.

WHO Western Pacifi Region. Road map for surveillance and monitoring of HIV drug resistance in the Western Pacific region 2014-2018. 58 pages p.

Aghokeng AF, Monleau M, Eymard-Duvernay S, Dagnra A, Kania D, Ngo-Giang-Huong N, et al. Extraordinary heterogeneity of virological outcomes in patients receiving highly antiretroviral therapy and monitored with the World Health Organization public health approach in sub-saharan Africa and southeast Asia. Clin Infect Dis. 2014;58(1):99-109.

Do D, Agneskog E, Nguyen T, Santacatterina M, Sönnerborg A, Larsson M. Monitoring the efficacy of antiretroviral therapy by a simple reverse transcriptase assay in HIV-infected adults in rural Vietnam. Future Virol. 2012;7(9 ):923–31.

WHO. Road Map for surveillance and monitoring of HIV drug resistance in the Western Pacific Region (2014-2018). Manila, Philippines: World Health Organization Regional Office for the Western Pacific; 2014. Available from: http://www.wpro.who.int/hiv/documents/docs/hivdr_roadmap/en/.

Rangarajan S, Donn JC, Giang le T, Bui DD, Hung Nguyen H, Tou PB, et al. Factors associated with HIV viral load suppression on antiretroviral therapy in Vietnam. J Virus Erad. 2016;2(2):94-101.

Published

20-08-2018

How to Cite

1.
Dat VQ, Duong BD, Nhan DT, Hai NH, Anh NTL, Thu HHK, Ton T, Anh LQ, Nghia NT, Thuong NV, Nghia KV, Tam TTM, Hau TP, Phuc ND, Thinh VX, Lien TTX, Hien NT, Bertagnolio S, Van NTT, Kato M. Viral load suppression and acquired HIV drug resistance in adults receiving antiretroviral therapy in Viet Nam: results from a nationally representative survey. Western Pac Surveill Response J [Internet]. 2018 Aug. 20 [cited 2024 Nov. 3];9(3). Available from: https://ojs.wpro.who.int/ojs/index.php/wpsar/article/view/596

Issue

Section

Original Research

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