Circulation of influenza B lineages in northern Viet Nam, 2007–2014
DOI:
https://doi.org/10.5365/wpsar.v6i4.328Abstract
Introduction: Influenza B viruses circulated throughout Vietnam and their activities peaked in spring seasons (Jan-Apr) usually. There are two antigenic distinct lineages of influenza B viruses have been co-circulating in the past 20 years, however, only one lineage is selected as a component of current trivalent seasonal influenza vaccine. To improve understanding about the ILI impact of influenza B lineages in the tropical regions and mismatch of circulating B lineage with influenza vaccine, we identified the virus lineages circulating in the North of Vietnam over eight years-period (2007-2014).
Methods: Lineage of 331 influenza B viruses was characterized by hemagglutination inhibition (HAI) against standard reference ferret/sheep antiserum provided by WHO. Partial genome sequence analysis of hemagglutinin (HA) was performed in 64 influenza B isolates during 2010-2014.
Results: The results showed a proportion of influenza B lineages viruses changing by years: the Yamagata lineage predominated in three years of study 2007, 2008 and 2012, while the Victoria lineage had a great proportion for five years during 2009- 2014 period. Two divergent influenza B lineages showed continued evolution with time. The North Hemisphere’s vaccine components were mismatched with predominated viruses circulation in 2007, 2009 and 2014.
Discussion: The seasonality of influenza activity is more variable in the tropical and subtropical regions compared with the temperate zone. Our basic data collected among seven years showed a common co-circulation of both lineages in the North of Vietnam and the chance of success in predicting the predominant lineage proved to be difficult. Quadrivalent influenza vaccines may improve the effectiveness of influenza vaccine program in the future
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For example, Hoy D, Saketa ST, Maraka RR, Sio A, Wanyeki I, Frison P, et al. Enhanced syndromic surveillance for mass gatherings in the Pacific: a case study of the 11th Festival of Pacific Arts in Solomon Islands, 2012. Western Pac Surveill Response J. 2016;7:3. doi:10.5365/wpsar.2016.7.1.004 pmid:27766181
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