Serotype distribution and antimicrobial resistance of Streptococcus pneumoniae in the Philippines, 2012–2018

Authors

  • Sonia B Sia Research Institute for Tropical Medicine, Department of Health, Manila, Philippines
  • Marietta L Lagrada Research Institute for Tropical Medicine, Department of Health, Manila, Philippines
  • June M Gayeta Research Institute for Tropical Medicine, Department of Health, Manila, Philippines
  • Melissa Ana L Masim Research Institute for Tropical Medicine, Department of Health, Manila, Philippines
  • Jaywardeen P Abad Research Institute for Tropical Medicine, Department of Health, Manila, Philippines
  • Mariane A Magbanua Research Institute for Tropical Medicine, Department of Health, Manila, Philippines
  • Ferissa Buensalida Ablola Research Institute for Tropical Medicine, Department of Health, Manila, Philippines

DOI:

https://doi.org/10.5365/wpsar.2021.12.4.834

Abstract

Objective: Data are scarce on the prevailing Streptococcus pneumoniae serotypes in the Philippines, including the relative antimicrobial resistance (AMR) of these bacteria. This study is designed to fill that gap by describing the serotype distribution and AMR of S. pneumoniae in the Philippines from 2012 to 2018.

Methodology: S. pneumoniae isolates from clinical specimens were collected through the Philippine Department of Health Antimicrobial Resistance Surveillance Program from 1 January 2012 to 31 December 2018. Identification and antimicrobial susceptibility testing (AST) were performed using conventional and automated methods (Vitek2 Compact Automated Machine). AST for penicillin, erythromycin, co-trimoxazole, ceftriaxone and levofloxacin was done following the Clinical and Laboratory Standard Institute recommendations. Serotyping was done through slide agglutination following the Denka Seiken slide agglutination method.

Results: From a total of 307 isolates of S. pneumoniae, 32 serotypes were identified; the most frequently occurring were serotypes 1, 3, 5, 4, 18, 19A, 6B, 15 and 14. Many (n=113, 36.53%) of the isolates were from those aged <5 years. Pneumococcal conjugate vaccine (PCV) coverage was as follows: PCV7 (32.69%), PCV10 (54.16%) and PCV13 (69.23%). The overall AMR of invasive S. pneumoniae isolates was low. Penicillin-resistant serotypes were 14, 19, 24, 4, 5, 1, 15, 6 and 32.

Discussion: With the inclusion of PCV13 in the National Immunization Program, continued monitoring of the prevailing serotypes of S. pneumoniae isolates in the Philippines is needed to guide disease and AMR control measures.

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Published

29-11-2021

How to Cite

1.
Sia SB, Lagrada ML, Gayeta JM, Masim MAL, Abad JP, Magbanua MA, Ablola FB. Serotype distribution and antimicrobial resistance of Streptococcus pneumoniae in the Philippines, 2012–2018. Western Pac Surveill Response J [Internet]. 2021 Nov. 29 [cited 2024 Jun. 25];12(4):8. Available from: https://ojs.wpro.who.int/ojs/index.php/wpsar/article/view/834

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Section

Original Research

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