Estimating the national burden of hospitalizations for influenza-associated severe acute respiratory infection in the Lao People’s Democratic Republic, 2016

Authors

  • Bouaphanh Khamphaphongphane National Center for Laboratory and Epidemiology, Vientiane, Lao People’s Democratic Republic
  • May Chiew WHO Health Emergencies Programme, World Health Organization, Vientiane, Lao People’s Democratic Republic
  • Joshua Mott Influenza Division, Thailand Regional Influenza Program, United States Centers for Disease Control and Prevention, Nonthaburi, Thailand
  • Sombandith Khamphanoulath National Center for Laboratory and Epidemiology, Vientiane, Lao People’s Democratic Republic
  • Viengphone Khanthamaly Influenza Division, United States Centers for Disease Control and Prevention, US Embassy, Vientiane, Lao People’s Democratic Republic
  • Keooudomphone Vilivong National Center for Laboratory and Epidemiology, Vientiane, Lao People’s Democratic Republic; Influenza Division, United States Centers for Disease Control and Prevention, US Embassy, Vientiane, Lao People’s Democratic Republic
  • Thongchanh Sisouk National Center for Laboratory and Epidemiology, Vientiane, Lao People’s Democratic Republic
  • Leila Bell Health Emergency Information and Risk Assessment, WHO Health Emergencies Programme, World Health Organization, Regional Office for the Western Pacific, Manila, Philippines
  • Erica Dueger Infectious Hazards Management, WHO Health Emergencies Programme, World Health Organization, Regional Office for the Western Pacific, Manila, Philippines; Influenza Division, United States Centers for Disease Control and Prevention, Atlanta, GA, United States of America; Sanofi Pasteur, Lyon, France
  • Sheena Sullivan WHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, Melbourne, and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia
  • Angela Daniella Iuliano Influenza Division, United States Centers for Disease Control and Prevention, Atlanta, GA, United States of America
  • Reiko Tsuyuoka WHO Health Emergencies Programme, World Health Organization, Vientiane, Lao People’s Democratic Republic
  • Onechanh Keosavanh National Center for Laboratory and Epidemiology, Vientiane, Lao People’s Democratic Republic

DOI:

https://doi.org/10.5365/wpsar.2020.11.2.001

Abstract

Objective: Estimates of the burden of influenza are needed to inform prevention and control activities for seasonal influenza, including to support the development of appropriate vaccination policies. We used sentinel surveillance data on severe acute respiratory infection (SARI) to estimate the burden of influenza-associated hospitalizations in the Lao People’s Democratic Republic.

Methods: Using methods developed by the World Health Organization, we combined data from hospital logbook reviews with epidemiological and virological data from influenza surveillance from 1 January to 31 December 2016 in defined catchment areas for two sentinel sites (Champasack and Luang Prabang provincial hospitals) to derive population-based estimates of influenza-associated SARI hospitalization rates. Hospitalization rates by age group were then applied to national age-specific population estimates using 2015 census data.

Results: We estimated the overall influenza-associated SARI hospitalization rate to be 48/100 000 population (95% confidence interval [CI]: 44–51) or 3097 admissions (95% CI: 2881–3313). SARI hospitalization rates were estimated to be as low as 40/100 000 population (95% CI: 37–43) and as high as 92/100 000 population (95% CI: 87–98) after accounting for SARI patient underascertainment in hospital logbooks. Influenza-associated SARI hospitalization rates were highest in children aged <5 years (219; 95% CI: 198–241) and persons aged >=65 years (106; 95% CI: 91–121).

Discussion: Our findings have identified age groups at higher risk for influenza-associated SARI hospitalization, which will support policy decisions for influenza prevention and control strategies, including for vaccination. Further work is needed to estimate the burdens of outpatient influenza and influenza in specific high-risk subpopulations.

Author Biography

May Chiew, WHO Health Emergencies Programme, World Health Organization, Vientiane, Lao People’s Democratic Republic

Tecnical Officer (Epidemiologist)

WHO Health Emergencies Programme

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Published

22-06-2021

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Original Research