An investigation of a measles outbreak in Japan and Taiwan, China, March–May 2018

Authors

  • Kazuki Shimizu Graduate School of Medicine, Hokkaido University, Japan
  • Ryo Kinoshita Graduate School of Medicine, Hokkaido University, Japan
  • Keita Yoshii Graduate School of Medicine, Hokkaido University, Japan
  • Andrei R Akhmetzhanov Graduate School of Medicine, Hokkaido University, Japan
  • Sungmok Jung Graduate School of Medicine, Hokkaido University, Japan
  • Hyojung Lee Graduate School of Medicine, Hokkaido University, Japan
  • Hiroshi Nishiura Graduate School of Medicine, Hokkaido University, Japan

DOI:

https://doi.org/10.5365/wpsar.2018.9.2.005

Abstract

Objective: To investigate a measles outbreak that spread to Japan and China, Taiwan, China during March–May 2018, exploring the characteristics of the super-spreading event.

Methods: A contact investigation of the index case and reconstruction of the epidemiological dynamics of measles transmission were conducted. Employing a mathematical model, the effective reproduction number was estimated for each generation of cases.

Results and discussion: A single index case gave rise to a total of 38 secondary cases, 33 in Japan and five in China, Taiwan, China. Subsequent chains of transmission were observed in highly vaccinated populations in both Japan and China, Taiwan, China. The effective reproduction number of the second generation was > 1 for both Japan and China, Taiwan, China. In Japan, the reproduction number was estimated to be < 1 during the third generation. Vaccination of susceptible individuals is essential to prevent secondary and tertiary transmission events.

Author Biography

Hiroshi Nishiura, Graduate School of Medicine, Hokkaido University, Japan

Professor

Department of Hygiene

Graduate School of Medicine, Hokkaido University

References

References

Durrheim DN, Crowcroft NS, Strebel PM. Measles – The epidemiology of elimination. Vaccine 2014;32:6880-3.

Perry RT, Gacic-Dobo M, Dabbagh A, Mulders MN, Strebel PM, Okwo-Bele JM, Rota PA, Goodson JL; Centers for Disease Control and Prevention (CDC). Progress toward regional measles elimination--worldwide, 2000-2013. Morbid Mortal Wkly Rep 2014;63:1034-8.

Hagan JE, Kriss JL, Takashima Y, Mariano KML, Pastore R, Grabovac V, Dabbagh AJ, Goodson JL. Progress towards measles elimination, Western Pacific Region, 2013–2017. WHO Weekly Epidemiological Record 2018;93(18):229-40.

Choe YJ, Jee Y, Oh MD, Lee JK. Measles Elimination Activities in the Western Pacific Region: Experience from the Republic of Korea. J Korean Med Sci 2015;30:S115-21.

Inaida S, Matsuno S, Kobune F. Measles elimination and immunisation: national surveillance trends in Japan, 2008-2015. Epidemiol Infect 2017;145:2374-81.

Filia A, Bella A, Del Manso M, Baggieri M, Magurano F, Rota MC. Ongoing outbreak with well over 4,000 measles cases in Italy from January to end August 2017 - what is making elimination so difficult? Euro Sruveill 2017;22:pii=30614.

Tanaka-Taya K. Current situation of measles in Japan, 2017. Uirusu 2017;67:17-24 (in Japanese with English abstract).

Nishiura H, Mizumoto K, Asai Y. Assessing the transmission dynamics of measles in Japan, 2016. Epidemics 2017;20:67-72.

Kinoshita R, Nishiura H. Assessing age-dependent susceptibility to measles in Japan. Vaccine 2017;35:3309-17.

National Institute of Infectious Diseases, Japan. On the occurrence of measles cases associated with Okinawa prefecture (up to 19 April 2018). Tokyo: National Institute of Infectious Diseases, 2018 (in Japanese), Available from: https://www.niid.go.jp/niid/ja/id/655-disease-based/ma/measles/idsc/7990-measles20180419.html

Centers for Disease Control, Republic of China (Taiwan). Taiwan CDC advises public to determine need for measles vaccination and get vaccinated prior to traveling overseas as this year’s first imported measles case confirmed. Taipei: Centers for Disease Control, 2018. Available from: https://www.cdc.gov.tw/english/info.aspx?treeid=BC2D4E89B154059B&nowtreeid=EE0A2987CFBA3222&tid=0E8B646FA6018F3A

Center for Disease Control and Prevention (CDC). Progress toward measles elimination--Japan, 1999-2008. MMWR Morb Mortal Wkly Rep. 2008;57:1049–1052.

Ergonul O, Can F, Akova M, Madoff L, Emerging Infectious Diseases: Clinical Case Studies, Academic press, 2014.

Mizumoto K, Kobayashi T, Chowell G. Transmission potential of modified measles during an outbreak, Japan, March-May 2018. Euro Surveill 2018;23(24).

Centers for Disease Control, Republic of China (Taiwan), 2018. Available from: https://www.cdc.gov.tw/english/info.aspx?treeid=BC2D4E89B154059B&nowtreeid=EE0A2987CFBA3222&tid=A414238B117BBBE3

Okinawa prefecture, Japan. On the occurrence of measles. Naha: Okinawa prefecture (in Japanese), 2018. Available from: http://www.pref.okinawa.jp/site/hoken/eiken/kikaku/kansenjouhou/measles.html

Aichi prefecture, Japan. On the occurrence of measles. Nagoya: Aichi prefecture (in Japanese), 2018. Available from: http://www.pref.aichi.jp/soshiki/kenkotaisaku/0000013280.html

Kanagawa Prefectural Institute of Public Health, Japan. On the occurrence of measles. Chigasaki: Kanagawa Prefecture (in Japanese), 2018. Available from:

http://www.eiken.pref.kanagawa.jp/003_center/0005_ryukou/masin/180510_masin.html

Tokyo Metropolitan Infectious Disease Surveillance Center, Japan. On the occurrence of measles. Tokyo: Tokyo Metropolitan Government (in Japanese), 2018. Available from:

http://idsc.tokyo-eiken.go.jp/diseases/measles/measles/

Klinkenberg D, Nishiura H. The correlation between infectivity and incubation period of measles, estimated from households with two cases. J Theor Biol 2011;284:52-60.

Published

22-08-2018

How to Cite

1.
Shimizu K, Kinoshita R, Yoshii K, Akhmetzhanov AR, Jung S, Lee H, Nishiura H. An investigation of a measles outbreak in Japan and Taiwan, China, March–May 2018. Western Pac Surveill Response J [Internet]. 2018 Aug. 22 [cited 2024 Dec. 22];9(3). Available from: https://ojs.wpro.who.int/ojs/index.php/wpsar/article/view/634

Issue

Section

Original Research