Prevalence of resistance to second-line tuberculosis drug among multidrug-resistant tuberculosis patients in Viet Nam, 2011

Authors

  • Hoa Binh Nguyen National Tuberculosis Control Programme Viet Nam, Hanoi, Viet Nam; Centre for Operational Research, International Union Against Tuberculosis and Lung Disease, Paris, France
  • Nhung Viet Nguyen National Tuberculosis Control Programme Viet Nam, Hanoi, Viet Nam; Viet Nam Association for Tuberculosis and Lung Disease, Hanoi, Viet Nam
  • Huong Thi Giang Tran Ministry of Health, Department of International Cooperation, Viet Nam
  • Hai Viet Nguyen Hanoi Medical University, Hanoi, Viet Nam
  • Quyen Thi Tu Bui Hanoi School of Public Health, Hanoi, Viet Nam

DOI:

https://doi.org/10.5365/wpsar.2016.7.2.002

Abstract

Introduction: Extensively drug-resistant tuberculosis (XDR-TB) represents an emerging public health problem worldwide. According to the World Health Organization, an estimated 9.7% of multidrug-resistant TB (MDR-TB) cases are defined as XDR-TB globally. The objective of this study was to determine the prevalence of drug resistance to second-line TB drugs among MDR-TB cases detected in the Fourth National Anti-Tuberculosis Drug Resistance Survey in Viet Nam.

Methods: Eighty clusters of TB cases were selected using a probability-proportion-to-size approach. To identify MDR-TB cases, drug susceptibility testing (DST) was performed for the four major first-line TB drugs. DST of second-line drugs (ofloxacin, amikacin, kanamycin, capreomycin) was performed on isolates from MDR-TB cases to identify pre-XDR and XDR cases.

Results: A total of 1629 smear-positive TB cases were eligible for culture and DST. Of those, DST results for first-line drugs were available for 1312 cases, and 91 (6.9%) had MDR-TB. Second-line DST results were available for 84 of these cases. Of those, 15 cases (17.9%) had ofloxacin resistance and 6.0% were resistant to kanamycin and capreomycin. Five MDR-TB cases (6.0%) met the criteria of XDR-TB.

Conclusion: This survey provides the first estimates of the proportion of XDR-TB among MDR-TB cases in Viet Nam and provides important information for local policies regarding second-line DST. Local policies and programmes that are geared towards TB prevention, early diagnosis and treatment with effective regimens are of high importance.

Downloads

Published

19-10-2016

How to Cite

1.
Nguyen HB, Nguyen NV, Tran HTG, Nguyen HV, Bui QTT. Prevalence of resistance to second-line tuberculosis drug among multidrug-resistant tuberculosis patients in Viet Nam, 2011. Western Pac Surveill Response J [Internet]. 2016 Oct. 19 [cited 2026 Apr. 1];7(2). Available from: https://ojs.wpro.who.int/ojs/index.php/wpsar/article/view/433

Issue

Vol. 7 No. 2 (2016): April – June

Section

Original Research

License

You are free to:

  • Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
  • Adapt — remix, transform, and build upon the material for any purpose, even commercially.
  • The licensor cannot revoke these freedoms as long as you follow the license terms.

Under the following terms:

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Notices:

When the Licensor is an intergovernmental organization, disputes will be resolved by mediation and arbitration unless otherwise agreed.

You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation.

No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.

Most read articles by the same author(s)