An assessment of measles vaccine effectiveness, Australia, 2006–2012

Authors

  • Alexis Pillsbury The National Centre for Immunisation Research and Surveillance (NCIRS), Australia
  • Helen Quinn Discipline of Paediatrics and Child Health, University of Sydney, The Children’s Hospital at Westmead, Westmead, New South Wales, Australia.

DOI:

https://doi.org/10.5365/wpsar.2015.6.2.007

Abstract

Objective: Vaccine effectiveness analysis serves as a critical evaluation for immunization programmes and vaccination coverage. It also contributes to maintaining public confidence with the vaccine providers. This study estimated measles vaccine effectiveness at the population level using Australian national notifications data between 2006 and 2012.

Methods: Notification data were obtained from the National Notifiable Diseases Surveillance System. Vaccination status was classified according to whether a case had received zero, one or two doses of measles-containing vaccine. Cases aged less than 1 year and those with unknown vaccination status were excluded. All children with disease onset between 1 January 2006 and 31 December 2012 who were born after 1996 were included. Cases were matched to controls extracted from the Australian Childhood Immunization Register according to date of birth and jurisdiction of residence. Vaccine effectiveness was estimated by conditional logistic regression. Sensitivity analyses were conducted to test data robustness.

Results: Vaccine effectiveness was estimated at 96.7% (95% confidence interval [CI]: 94.5–98.0%) for one dose and 99.7% (95% CI: 99.2–99.9%) for two doses of measles vaccine. For at least one dose, effectiveness was estimated at 98.7% (95% CI: 97.9–99.2%). Sensitivity analyses did not significantly alter the base estimates.

Discussion: Vaccine effectiveness estimates suggested that the measles vaccine was protective at the population level between 2006 and 2012. However, vaccination coverage gaps may have contributed to recent measles outbreaks and may represent a serious barrier for Australia to maintain measles elimination status.

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Published

09-07-2015

How to Cite

1.
Pillsbury A, Quinn H. An assessment of measles vaccine effectiveness, Australia, 2006–2012. Western Pac Surveill Response J [Internet]. 2015 Jul. 9 [cited 2026 Apr. 2];6(3). Available from: https://ojs.wpro.who.int/ojs/index.php/wpsar/article/view/346

Issue

Vol. 6 No. 3 (2015): July – September

Section

Original Research

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