Issue 1, January – March 2015

Hospital preparedness for Ebola virus disease: a training course in the Philippines

Original Research

Celia Carlos,a Rowena Capistrano,a Charissa Fay Tobora,a Mari Rose delos Reyes,a Socorro Lupisan,a Aura Corpuz,b Charito Aumentado,b Lyndon Lee Suy,c Julie Hall,b Julian Donald,b Megan Counahan,b Melanie S Curless,d Wendy Rhymer,e Melanie Gavin,d Chelsea Lynch,d Meredith A Black,d Albert D Anduyon,a Petra Buttnerf and Rick Spearef,g

a Research Institute for Tropical Medicine, Alabang, Philippines.
b Office of the WHO Representative in the Philippines, Manila, Philippines.
c National Center for Disease Prevention and Control, Department of Health, Manila, Philippines.
d Johns Hopkins Hospital, Hospital Epidemiology and Infection Control, Baltimore, Maryland, United States of America.
e Consultant, Winnipeg, Manitoba, Canada.
f Tropical Health Solutions Pty Ltd, Townsville, Australia.
g College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Australia.

Correspondence to Rick Speare (e-mail: rickspeare@gmail.com).


To cite this article:

Carlos C et al. Hospital preparedness for Ebola virus disease: a training course in the Philippines. Western Pacific Surveillance and Response Journal, 2015, 6(1):33–43. doi:10.5365/wpsar.2014.5.4.008


Abstract

Objective: To develop, teach and evaluate a training workshop that could rapidly prepare large numbers of health professionals working in hospitals in the Philippines to detect and safely manage Ebola virus disease (EVD). The strategy was to train teams (each usually with five members) of key health professionals from public, private and local government hospitals across the Philippines who could then guide Ebola preparedness in their hospitals.

Methods: The workshop was developed collaboratively by the Philippine Department of Health and the country office of the World Health Organization. It was evaluated using a pre- and post-workshop test and two evaluation forms. Chi-square tests and linear regression analyses were conducted comparing pre- and post-workshop test results.

Results: A three-day workshop was developed and used to train 364 doctors, nurses and medical technologists from 78 hospitals across the Philippines in three initial batches. Knowledge about EVD increased significantly (P < 0.009) although knowledge on transmission remained suboptimal. Confidence in managing EVD increased significantly (P = 0.018) with 96% of participants feeling more prepared to safely manage EVD cases.

Discussion: The three-day workshop to prepare hospital staff for EVD was effective at increasing the level of knowledge about EVD and the level of confidence in managing EVD safely. This workshop could be adapted for use as baseline training in EVD in other developing countries to prepare large numbers of hospital staff to rapidly detect, isolate and safely manage EVD cases.


Introduction

The West African Ebola virus disease (EVD) outbreak was declared a public health emergency of international concern (PHEIC) by the World Health Organization (WHO) on 8 August 2014.1 This outbreak is unprecedented with ongoing transmission in Guinea, Liberia and Sierra Leone and secondary localized outbreaks in Mali, Nigeria, Spain and the United States of America. Although estimates vary, the case fatality rate (CFR) is high in the three West African countries with ongoing transmission: cumulative CFR for the outbreak on 24 December 2014 was 70% for cases with a recorded definitive outcome; 58–60% for hospitalized patients; and 55% (359/649) for health-care workers (HCWs).2 Using the total figures for Guinea, Liberia and Sierra Leone gives a cumulative CFR of 39% (7574/19 463) for all probable and confirmed cases, an underestimate of CFR since the fate of apparently more than 2000 cases are unknown.2 This EVD outbreak was the third PHEIC to be declared under the International Health Regulations (2005) (IHR). IHR is a legal framework that directs and governs its signatories’ activities, aiming to protect the global community from public health risks and emergencies that cross international borders.3 At its core is the obligation for countries to develop, strengthen and maintain public health capacities for surveillance and response to be able to detect, assess, notify and report events and respond to a PHEIC.3

The West African EVD outbreak is considered such a threat to global security that for the first time the United Nations General Assembly, supported by the United Nations Security Council, mandated a United Nations Mission for Ebola Emergency Response for a public health event.4

In 2013 the Philippines had 2.295 million formally registered Overseas Filipino Workers (OFW).5 Of these, 1700 (< 1%) were registered in Africa. However, the Commission on Filipinos Overseas estimated in 2012 there were 10.46 million Filipinos working overseas either permanently or temporarily.6 Their estimate in the Ebola-affected countries of Guinea, Liberia and Sierra Leone was 1212.6 It is traditional for OFW to return to the Philippines in high numbers at Christmas time.7

The Philippine Department of Health (DOH) is experienced with the management of outbreaks and has a relatively robust surveillance system with a history of managing imported emerging and re-emerging infectious diseases.8–10

It was against this backdrop of the risk of global transmission and returning OFW that the DOH asked the WHO country office in the Philippines for assistance in designing and implementing a training workshop to prepare government and private health practitioners in the management of EVD.

Countries unaffected by EVD, such as the Philippines, are required to prepare for the introduction of cases. Even if no EVD cases occur, symptomatic travellers from West Africa who meet the case definition of suspected EVD have to be managed according to the same protocols until they are confirmed as EVD negative.11 Although briefings for health care workers (HCWs) in Ebola treatment centres have been published,12–14 we were unable to locate a course designed to prepare clinicians for imported EVD in developing country settings.

The goal of the training was to increase capacity to rapidly detect, isolate and safely care for EVD cases within the Philippine health system, both public and private. The aims of the workshop were for participants to be able to provide safer care for patients with EVD and to prevent disease transmission in the health-care and community settings. The strategy was to train teams (each usually with five members) of key health professionals from public, private and local government hospitals across the Philippines who could then guide Ebola preparedness in their hospitals. The focus was on hospitals since it is highly likely that, if EVD occurs in the Philippines, patients will be identified and managed in hospitals. Although the DOH has appointed some hospitals to be EVD referral hospitals, the initial presentation of cases could occur at any hospital. To ensure that participants followed official guidelines, the workshop was based on the DOH’s Interim Guidelines for the Prevention and Management of Ebola Virus Disease (26 August 2014).

The aim of this paper is to describe the training programme and its evaluation.

Methods

Setting

The curriculum and content were developed collaboratively by the Research Institute for Tropical Medicine (RITM, the DOH research institute for infectious diseases), the WHO country office and consultants employed by WHO as private individuals or from Johns Hopkins Hospital and Tropical Health Solutions. RITM, located in Metropolitan Manila, has a large training centre and staff experienced in running workshops. Training laboratories were available for practical sessions, and RITM’s infection control team (experienced with SARS and other emerging infectious diseases) played a major role.

Workshops

Each workshop extended over three days and consisted of 18 lectures and 10 practical or small group sessions, including three practical sessions to don (put on) and doff (take off) personal protective equipment (PPE) (Table 1).15 Everyone participated in at least two PPE sessions. At registration, every participant was given one set of PPE (apart from rubber boots) for personal use during the workshop. The PPE sessions were conducted in large groups numbering from 50 to 120 (Figure 1). PPE donning and doffing skills were first demonstrated to the whole group, which was then divided into two groups for demonstration and practice. Rigid donning and doffing protocols were followed and overseen by participants acting as trained observers supervised by course facilitators. In the final PPE session, red water-based paint was applied to the PPE to simulate contamination by body fluids, adding a sense of realism to the doffing process (Figure 2).


Table 1. Structure of workshop on hospital management of EVD*

* Modules and guide are available at http://www.wpro.who.int/philippines/mediacentre/features/ebolatraining_materials/en/.
DOH, Department of Health; EVD, Ebola virus disease; PPE, personal protective equipment; UV, ultraviolet rays; WHO, World Health Organization.


Figure 1. Donning and doffing PPE during the Philippine DOH Ebola preparedness workshop*

Source: Photo taken by the Research Institute for Tropical Disease photographer.
* Each health-care provider worked with a trained observer. Facilitators supervised groups of participants. Tape on the floor helped simulate workflow by identifying low and high risk areas.


Figure 2. Water-based red paint has been applied to a participant’s PPE to simulate extensive contamination by blood*

Source: Photo taken by Rick Speare.
* Gloves, gown and the clear, disposable apron are contaminated.


A specialized series of three lectures and a practical session were run separately for medical technologists (Table 1). In the Philippines, medical technologists have a Bachelor of Science in Medical Technology and are equivalent to laboratory scientists in other countries. The medical technologists’ sessions included opportunities to practise venepuncture and use laboratory equipment while wearing EVD PPE. At the closing session on Day 3, the Director of RITM and the WHO Representative or their delegates gave closing speeches and presented certificates of participation.

Participants

Since the DOH wished to rapidly and extensively distribute EVD knowledge and skills, three initial workshops were held from 28 October to 13 November 2014 with large numbers of participants in each. Hospitals selected by the DOH from each province were asked to send a team of five including at least one doctor, one nurse and one medical technologist. Batches 1, 2 and 3 had 127, 115 and 122 participants, respectively, from 78 hospitals (21 regional hospitals, 22 private hospitals and 35 local government hospitals).

The training programme for each batch of trainees was modified as new evidence was reported in the literature or online by the Centers for Disease Control and Prevention (CDC) and WHO.16,17

Evaluation

Three tools were used to evaluate the workshop: a pre- and post-workshop test, two evaluation forms post-workshop and One Minute Reflections (OMR)18 on Days 1 and 2. The test was developed by WHO consultants and piloted on RITM medical and nursing staff; the RITM evaluation form is used routinely for all workshops, and the EVD-specific evaluation form was a modification of the Johns Hopkins Hospital form used for EVD training workshops. All questionnaires were anonymous.

Effect of the workshop on knowledge was tested using a pre- and post-workshop test administered on Day 1 before the lectures commenced and on Day 3 before the final practical session on PPE. Knowledge was assessed by 10 questions. Confidence in being able to manage EVD was assessed on a five-point Likert scale (strongly disagree, disagree, neither disagree or agree, agree and strongly agree) in response to the statement: “I am confident that I can be safe when caring for a patient with Ebola virus disease.” The answers were summarized and presented to the participants before the closing session on Day 3.

At the end of activities on Days 1 and 2 participants were asked to complete the OMR which asked two questions: (1) What was the most useful, meaningful or intriguing thing/s that you learnt during this day? and (2) what question/s remains uppermost in your mind as we end this day? The responses from the OMR were addressed in the first sessions on Days 2 and 3.

Statistical analysis

Pre- and post-workshop test: If a response to one of the 10 knowledge questions was missing, it was set to being incorrect. The number of missing values per question ranged between 0 and 4 for the pre-workshop test and between 0 and 6 for the post-workshop test. The 10 knowledge questions were recoded to 0 for “incorrect” and 1 for “correct” and added up to get the overall number of correct answers. This outcome variable was logarithmically transformed to achieve approximate normal distribution for the linear regression analysis. Pre- and post-workshop participants were analysed as unpaired data because questionnaires could not be linked.

Categorical characteristics are described using absolute and relative frequencies. Age was described using mean value and standard deviation. The number of correct answers given to the 10 knowledge questions was described using median value and inter-quartile range (IQR). Confidence intervals of 95% were calculated for correct answers to knowledge questions; pre- and post-workshop test results were compared using chi-square tests. The overall logarithmically transformed number of correct answers pre- and post-training were compared using linear regression. Linear regression analysis was conducted to analyse whether profession, age and gender showed independent effects on the logarithmically transformed number of correct answers post-workshop. Profession and gender were dummy coded for this analysis, while age was initially considered, continuous and was then categorized using the quartiles and dummy coded. Chi-square tests were used to assess effects of age, gender and profession on level of confidence dealing with an Ebola case post-workshop. All analysis was adjusted for the cluster effect of the three workshops. Analysis was conducted using STATA, release 12.1 (StataCorp LP, College Station, Texas). Since this was an operational evaluation and findings were progressively used to improve the workshop, ethics approval was not sought.

Results

Participants

A total of 285 participants (78.3% of all participants) and 364 participants (100% of all participants) completed the pre- and post-workshop tests, respectively. For the pre- and post-workshop tests, respectively, participants were doctors (33.3% and 35.0%), nurses (42.9% and 40.0%), medical technologists (20.3% and 20.1%) and others (3.4% and 4.5%). Participants who completed the pre- and post-training participants were predominantly female (59.6% and 61.9%, respectively) and mean ages and ranges were the same at 38.2 (21 to 62 years).

Improvement in knowledge

Of the 10 knowledge questions, three were correctly answered by more than 90% of pre-workshop test participant (no skin exposed in EVD PPE, EVD waste handled differently, no embalming with EVD) (Table 2). For the other seven questions, pre-workshop knowledge was poor (< 50% correct) for two questions (transmission routes of EVD, correct mixing of 0.5% bleach). The percentage of correct answers rose by 10% or more in the post-workshop test for five questions (three of them statistically significant), remained largely unchanged for four (three of which had more than 90% correct in pre-test) and one fell by 16.9% (soap and water in EVD) but this did not achieve statistical significance (Table 2).


Table 2. Percentage and 95% confidence interval of correct responses to 10 knowledge questions pre- and post-workshop*

* Correct answers in parenthesis.
95% confidence intervals are cluster-adjusted.
p-values are results of cluster-adjusted chi-square tests.


The percentage of participants who correctly answered all 10 questions was 2.8% (8 of 285) and 22.5% (82 to 364) pre- and post-workshop, respectively. The number of questions correctly answered by participants rose from a pre-workshop median of seven (IQR = 6 to 8; range 3 to 10) to a post-workshop median of nine (IQR = 8 to 9; range 4 to 10)(P < 0.009) (Figure 3).


Figure 3. Percentage of knowledge questions correctly answered pre- and post-workshop

Profession (nurse P = 0.775, medical technologist P = 0.431, other P = 0.335, doctor = reference group), age (30–39 years P = 0.271; 40–44 years P = 0.273; ≥ 45 years P = 0.728; reference < 30 years) and gender (P = 0.071) showed no significant independent effects on the number of correct answers post-workshop (Table 3).


Table 3. Associations between number of correct responses and level of confidence post-workshop and age, gender and profession

* p-values are results of a linear regression model for post-workshop outcome including profession, age and gender as independent variables.
p-values are results of chi-square tests. P-values are adjusted for cluster-effect.
IQR, inter-quartile range.


Improvement in confidence

Participants’ level of confidence in safely caring for an EVD patient rose markedly by the end of the workshop (P = 0.018). Pre-workshop, 27.3% disagreed or strongly disagreed with the statement: “I am confident that I can be safe when caring for a patient with Ebola virus disease,” while post-training this percentage fell to 2.6% (P = 0.018). On the other hand, pre-workshop, 32.5% of participants agreed or strongly agreed with the statement; post-training this percentage had risen to 87.2%. The post-workshop level of confidence was not influenced by age (P = 0.412), gender (P = 0.404) or profession (P = 0.458) (Table 3).

Evaluations

Ratings in both evaluation forms were at the high end of a five-point Likert scale (Tables 4 and 5). The overall rating for the workshop was excellent (72.2%), good (26.7%), fair (0.6%) and poor (0%) (Table 4). To the question “Do you feel you are more prepared to screen for and manage patients with Ebola?” 96.4% of participants answered “Yes” (Table 5).


Table 4. Evaluation of the EVD workshop using the general RITM form (n = 328)

Table 5. Ratings on EVD-specific evaluation form (n = 333)

The OMR provided a useful means of addressing questions that were left unanswered after Days 1 and 2. These questions fell mainly into two areas: knowledge and support. The former category consisted largely of questions about the disease. The latter category included detailed questions about how things would be done if an EVD case occurred; where the specialized items of PPE could be obtained; funding for preparedness; and the roles of institutions, DOH and other government bodies. Questions on knowledge were answered by lecturers and RITM staff. On the last day, the Director of the Emerging Infectious Disease Control Programme was on hand to answer operational questions. His attendance was very important because the policy situation is dynamic and evolving.

Discussion

This three day workshop on hospital preparedness for EVD raised knowledge and increased the confidence of participants. Two areas of knowledge that were not as well understood that soap and water is effective for hand hygiene in EVD and the transmission of Ebola virus. The change in the former is understandable since during the practical sessions alcohol-based hand rubs were used for hand hygiene practice and to decontaminate gloves between doffing steps. Soap and water is recommended by WHO for hand hygiene for EVD if alcohol-based hand rubs are unavailable and as the preferred method if hands are visibly soiled.19 However, in many resource-limited settings sinks may not be available at point of care or may not have adequate soap or hand drying materials.20 This has been identified as a current problem in Liberian hospitals.21,22 In the workshop, emphasizing the indications for soap and water may have increased the correct answers.

Epidemiological studies in African communities have shown that direct contact with a symptomatic case of EVD is required for transmission.23–25 Interestingly, although an early study showed no transmission in the community without direct contact, one of the primary cases acquired EVD while visiting the local hospital in Sudan with no identified contact with a hospitalized EVD case.23 Conveying how EVD transmits in the health care setting remains a difficult issue.26,27 When two nurses in the USA acquired EVD while wearing PPE with no apparent breaches in protocol,28 standards of PPE for EVD were upgraded by both CDC and WHO.16,17 In hospitals and EVD isolation units the concept of “direct transmission” is confusing when it also includes transmission by needlestick, droplets and splashes and when aerosol transmission associated with clinical procedures (i.e. intubation) must be regarded as a risk.26 Although the correct answers for the question on transmission increased, it remained unacceptably low at 59.1%. We need to develop a new approach for conveying the complexities of transmission routes in the health-care setting.

The increase in level of confidence was verified by the pre- and post-workshop test and by two questions in the EVD-specific evaluation form. Improvement in the knowledge of participants, particularly in the practice of proper donning and doffing of PPE, could have contributed to this. In the OMR, participants often mentioned PPE as the most useful thing learnt. This workshop appeared to be effective in providing baseline training to raise awareness in large numbers of HCWs.

Screening and triage procedures were emphasized in lectures and reinforced by a practical session using the DOH screening and triage forms on six cases, illustrating the importance of a detailed travel, contact and illness history in the non-Ebola setting. Failure to screen and triage patients in the hospital setting in Liberia has led to infection of HCWs.21,29 Screening and triage are essential strategies to rapidly detect EVD patients in countries not affected by EVD and to prevent transmission.

We could find no specific guidelines for training HCWs in non-Ebola countries to be prepared to manage EVD. The approach we used trained teams of key health professionals from hospitals across the Philippines in the basics with the aim that they would train others when they returned home. In developed countries the focus appears to be on major hospitals, some designated for high consequence pathogens such as Ebola, to do intensive preparatory training.30–32 The former approach may be more suitable in countries with limited resources. In these settings, non-specialized clinicians will be expected to participate in the management of EVD patients. Providing basic training for large groups of HCWs may best protect the majority of HCWs. Once a case of EVD is identified, more intensive training can be provided to those HCWs managing the case to quickly build on the basic knowledge and skills. Although knowledge may not always be retained over time, brief educational intervention of eight hours duration for disaster preparedness was proven to be effective and to have a long-term impact on nurses’ knowledge.33

Limitations include use of the same test pre- and post-workshop, meaning increases in knowledge may be test- rather than disease-specific; and the 27.7% increase in responses for the post-workshop test which may breach the assumption that the pre- and post-workshop populations were the same. However, the professional, age and gender compositions of the samples were similar.

Although the context of the training was specific to the Philippines, the workshop could be adapted to other countries by substituting the Philippine DOH Interim Guidelines for EVD with each country’s own guidelines and omitting the lecture on Ebola Reston since this species of Ebola virus is endemic only in the Philippines and China.34,35 Mention of Ebola Reston in the background lecture on Ebola would be adequate for other developing countries.

Conclusions

The three-day workshop developed by the Philippine DOH to prepare hospital staff for EVD was effective at increasing the level of knowledge about EVD and the level of confidence in managing EVD safely. In an Ebola outbreak, additional specialized training in use of PPE would be needed for those caring for EVD patients in hospital to reinforce the baseline training. This workshop could be adapted for use in other developing countries preparing their hospital staff to rapidly detect, isolate and safely manage EVD cases.


Conflicts of interest

None declared.


Funding

Development and evaluation of the workshop and employment of WHO consultants (Speare, Rhymer, Curless, Lynch, Gavin and Black) was funded by the Department for International Development. Philippine DOH provided funds to conduct the workshop. All staff of RITM, DOH and WHO were funded by their respective employers under routine funding.
Acknowledgement

We thank a large number of staff of RITM for logistic support in developing and conducting workshops and the IT staff of RITM in particular for assistance in entering data from evaluation forms.


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